MRI offers a bridge between in vivo
imaging and histopathology. Based on microscopic changes in tissue structure or cellular composition observed by pathologists, we can test which pulse sequences will maximize our sensitivity to these features in ex vivo
samples, before finally transitioning these technologies to in vivo
use as disease biomarkers. This work represents a new collaboration between myself and researchers in the Penn Frontotemporal Dementia Center
This image shows (top) a histology slice, stained for iron, and a (bottom) matched slice from our ex vivo MRI, recapitulating the laminar distribution of iron in the cortex.